OpenDNA and Mayo Clinic presented a collaborative project at the American College of Cardiology (ACC) conference showcasing a new AI-powered model designed to predict coronary heart disease risk using polygenic risk scores (PRS). The study demonstrates the combined power of genetic and clinical data to support earlier, more personalized cardiovascular care.
Researchers from Mayo Clinic evaluated a group of 287 patients who had previously undergone calcium score testing. Over 15 years of follow-up, 35 coronary heart disease (CHD) events were identified through comprehensive chart reviews.
The AI model developed by OpenDNA showed a statistically significant correlation with CHD outcomes (p=0.001) and surpassed standard assessment methods like the Pooled Cohort Equations (PCE), with an AUC of 0.69 versus 0.67. When the Coronary Artery Calcium (CaC) score was included, performance rose to an AUC of 0.74. The model also achieved 80% sensitivity, 100% negative predictive value (NPV), and a 22.54% net reclassification improvement (NRI), suggesting meaningful advances in predictive capability.
Regis Fernandes, MD, FACC, FASE, FNLA, Chair of Comprehensive and Preventive Cardiology at Mayo Clinic in Arizona stated, “The results of this study showcase the strong potential of combining genomics and imaging data using AI to predict a patient’s risk of developing coronary heart disease. This represents a step forward in personalized cardiovascular care.”
“This study underscores OpenDNA’s commitment to leveraging AI in improving health outcomes by combining genomic data with multi-modality clinical data. The integration of AI into heart disease risk prediction not only has the potential to enhance accuracy but also to open new doors for early intervention and precision medicine.” said Dr. Eran Feldhay, CEO and Founder of OpenDNA.
The research provides encouraging evidence for incorporating AI and genetic risk data into future clinical strategies to prevent heart disease. Mayo Clinic has a financial interest in the technology referenced in this press release. Mayo Clinic will use any revenue it receives to support its not-for-profit mission in patient care, education and research.
